But be careful! I've heard from a number of folks who have gotten themselves into trouble with "cleaning" utilities. Keep in mind that OS X maintains multiple folders with identical names. These are not redundant duplicates.
Mr.Clean includes the option to "Exclude Library" which means that it won't look at many of your system's files. I recommend using this setting.
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Randy B. Singer
Co-author of The Macintosh Bible (4th, 5th, and 6th editions)
I've been using dupeguru. There are also music and picture edition links on the same page. When you download (if I remember correctly, click the I don't want to contribute button, but I think it's worth reading the fairware page.. It's a cool idea) dupeGuru - Duplicate file scanner
Gemini also does finds and deletes duplicates effectively if judge by users' reviews. It is available on the Mac App Store for $9.99 and is currently featured by Apple (Number one in New and Noteworthy category). However, it works only in OS X Lion for now.
I have used Dupe Guru as well, works well especially if you have a master folder and want to delete any other copies - but keep the master copies safe and sound, but also works just as well as a plain old duplicates finder
You can pay as little as $10 after you have given it a test, well worth the money
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