My take on this list:
1. Netscape Navigator (1994)--definitely deserving of this spot.
2. Apple II (1977)--also deserving.
3. TiVo HDR110 (1999)--not sure I'd put it this high, but it did make an impact.
4. Napster (1999)--I wouldn't even include this on the list.
5. Lotus 1-2-3 for DOS (1983)--surprised to see this and not VisiCalc here.
6. Apple iPod (2001)--should be right about here on a list.
7. Hayes Smartmodem (1981)--this too.
8. Motorola StarTAC (1996)--yes, but how is this the first cell on the list? There were others before it like the Digital Personal Communicator.
9. WordPerfect 5.1 (1989)--this does indeed belong here, but why not WordStar around here too?
10. Tetris (1985)--I'd say this is deserving of a spot, but maybe not this high.
11. Adobe Photoshop 3.0 (1994)--yes, but why wait for 3.0?
12. IBM ThinkPad 700C (1992)--good choice, but how does it beat the PowerBook 140/170?
13. Atari VCS/2600 (1977)--yes, since it was a revolution in console gaming.
14. Apple Macintosh Plus (1986)--correct choice for early Macs, since the 128K/512K wasn't as usable.
15. RIM BlackBerry 857 (2000)--this one seems right to me.
16. 3dfx Voodoo3 (1999)--not sure how this one got so high on the list.
17. Canon Digital Elph S100 (2000)--maybe too high on the list.
18. Palm Pilot 1000 (1996)--deserves a spot, even if the Newton was more innovative for its time.
19. id Software Doom (1993)--in my opinion, should not be on the list.
20. Microsoft Windows 95 (1995)--surprised this one isn't higher.
21. Apple iTunes 4 (2003)--this one, too, should be a little further up.
22. Nintendo Game Boy (1989)--I'd say it belongs, but maybe not this high. TI graphing calculators are more innovative, in my mind.
23. Iomega Zip Drive (1994)--maybe this one should have been lower.
24. Spybot Search & Destroy (2000)--OK choice, but not what I'd have at 24.
25. Compaq Deskpro 386 (1986)--sounds reasonable for the middle of the list.
26. CompuServe (1982)--yes, yes, and again yes; maybe could have been higher.
27. Blizzard World of Warcraft (2004)--does not deserve a spot on the list.
28. Aldus PageMaker (1985)--yes, this one does indeed belong and should be up further.
29. HP LaserJet 4L (1993)--not the first personal laser printer, but one of the most notable; should be a little higher.
30. Apple Mac OS X (2001)--should also be higher on the list.
31. Nintendo Entertainment System (1985)--sounds about right for 31st on the list, especially since it brought back the nearly dead home video game industry.
32. Eudora (1988)--great choice, why not a little higher on the list?
33. Sony Handycam DCR-VX1000 (1995)--OK with this one.
34. Apple Airport Base Station (1999)--also OK with this one.
35. Brøderbund The Print Shop (1984)--glad to see this getting some recognition; spot sounds about right too.
36. McAfee VirusScan (1990)--not the first, but I'll take it on the list.
37. Commodore Amiga 1000 (1985)--sounds good for #37.
38. ChipSoft TurboTax (1985)--yes, this one belongs; nice to see its original maker getting some credit for once.
39. Mirabilis ICQ (1996)--why this and not AIM?
40. Creative Labs Sound Blaster 16 (1992)--good card, good choice.
41. Apple HyperCard (1987)--yes, yes, and yes!!!
42. Epson MX-80 (1980)--sounds good for this spot.
43. Central Point Software PC Tools (1985)--surprise pick, but not a bad one.
44. Canon EOS Digital Rebel (2003)--another surprise pick, but again a good choice.
45. Red Hat Linux (1994)--surprised this one isn't higher.
46. Adaptec Easy CD Creator (1996)--OK choice, but maybe not my first pick for the list.
47. PC-Talk (1982)--good lower list choice.
48. Sony Mavica MVC-FD5 (1997)--yes, I approve of this one too.
49. Microsoft Excel (1985)--how is this one not a little higher?
50. Northgate OmniKey Ultra (1987)--why not the Model M keyboard?