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Message: <blockquote data-quote="Black" data-source="post: 1008929" data-attributes="member: 110346">Help required. I've been running OSX 10.6.2 without any problem for the last six months until today....Now when I try to run applications (other than Safari which is working slow, but otherwise ok) the application icon will appear in the dock for 2-3 seconds and then disappears without opening the program. I'm not aware that I've added or changed anything that might have triggered this problem.I can however open the applications without any problem if I boot into safe mode. I've tried more than one user profile, disk utilities, resetting PRAM, running Onyx maintenance utilities etc.  I'm at a loss as what to try next !</blockquote>