@MacInWin - hi Jake. Here is the EtreCheck data from the OP. PART 1
Crash 11/17/21
panic(cpu 0 caller 0xfffffe0025fdb4e0): "Failed to resume ACIOPHY from S2R: 0xe00002d6" @AppleT8103TypeCPhy.cpp:3640
Debugger message: panic
Memory ID: 0x1
OS release type: User
OS version: 21A559
Kernel version: Darwin Kernel Version 21.1.0: Wed Oct 13 17:33:01 PDT 2021; root:xnu-8019.41.5~1/RELEASE_ARM64_T6000
Fileset Kernelcache UUID: 3B2CA3833A09A383D66FB36667ED9CBF
Kernel UUID: 67BCB41B-BAA4-3634-8E51-B0210457E324
iBoot version: iBoot-7429.41.5
secure boot?: YES
Paniclog version: 13
KernelCache slide: 0x000000001ce58000
KernelCache base: 0xfffffe0023e5c000
Kernel slide: 0x000000001d680000
Kernel text base: 0xfffffe0024684000
Kernel text exec slide: 0x000000001d768000
Kernel text exec base: 0xfffffe002476c000
mach_absolute_time: 0x7d2b9f8e4
Epoch Time: sec usec
Boot : 0x6195e1d6 0x000b27a8
Sleep : 0x6195e749 0x000e4628
Wake : 0x6195e74a 0x0001a6b2
Calendar: 0x6195e74a 0x000cc34d
Zone info:
Foreign : 0xfffffe002c2e0000 - 0xfffffe002c2f4000
Native : 0xfffffe100079c000 - 0xfffffe300079c000
Readonly : 0 - 0
Metadata : 0xfffffe693ced8000 - 0xfffffe6948e2c000
Bitmaps : 0xfffffe6948e2c000 - 0xfffffe694e87c000
CORE 0 PVH locks held: None
CORE 1 PVH locks held: None
CORE 2 PVH locks held: None
CORE 3 PVH locks held: None
CORE 4 PVH locks held: None
CORE 5 PVH locks held: None
CORE 6 PVH locks held: None
CORE 7 PVH locks held: None
CORE 8 PVH locks held: None
CORE 9 PVH locks held: None
CORE 0 is the one that panicked. Check the full backtrace for details.
CORE 1: PC=0xfffffe00247f2c6c, LR=0xfffffe00247f2c6c, FP=0xfffffe60bab4bef0
CORE 2: PC=0xfffffe00247f2c6c, LR=0xfffffe00247f2c6c, FP=0xfffffe601144bef0
CORE 3: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe60ba8cbef0
CORE 4: PC=0xfffffe00247f2c6c, LR=0xfffffe00247f2c6c, FP=0xfffffe600c7abef0
CORE 5: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe60bac1bef0
CORE 6: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe60bb893ef0
CORE 7: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe601121bef0
CORE 8: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe600c5ebef0
CORE 9: PC=0xfffffe00247f2c70, LR=0xfffffe00247f2c6c, FP=0xfffffe60bac7bef0
Panicked task 0xfffffe150e0346a8: 0 pages, 518 threads: pid 0: kernel_task
Panicked thread: 0xfffffe1511f72f08, backtrace: 0xfffffe60bab0ad30, tid: 46853
lr: 0xfffffe00247be488 fp: 0xfffffe60bab0ada0
lr: 0xfffffe00247be158 fp: 0xfffffe60bab0ae10
lr: 0xfffffe00248fa558 fp: 0xfffffe60bab0ae30
lr: 0xfffffe00248ed2d4 fp: 0xfffffe60bab0aeb0
lr: 0xfffffe00248eac9c fp: 0xfffffe60bab0af70
lr: 0xfffffe00247737f8 fp: 0xfffffe60bab0af80
lr: 0xfffffe00247bddcc fp: 0xfffffe60bab0b320
lr: 0xfffffe00247bddcc fp: 0xfffffe60bab0b390
lr: 0xfffffe0024fbc748 fp: 0xfffffe60bab0b3b0
lr: 0xfffffe0025fdb4e0 fp: 0xfffffe60bab0b490
lr: 0xfffffe0025f7c52c fp: 0xfffffe60bab0b530
lr: 0xfffffe0025f797f8 fp: 0xfffffe60bab0b620
lr: 0xfffffe0025f62608 fp: 0xfffffe60bab0b750
lr: 0xfffffe0024eddd28 fp: 0xfffffe60bab0b7c0
lr: 0xfffffe0025f60768 fp: 0xfffffe60bab0b8f0
lr: 0xfffffe0025f69e70 fp: 0xfffffe60bab0b910
lr: 0xfffffe0024eddd28 fp: 0xfffffe60bab0b980
lr: 0xfffffe0025f69d50 fp: 0xfffffe60bab0ba60
lr: 0xfffffe0025d3baa4 fp: 0xfffffe60bab0bb20
lr: 0xfffffe0025d430b4 fp: 0xfffffe60bab0bbe0
lr: 0xfffffe0024eddd28 fp: 0xfffffe60bab0bc50
lr: 0xfffffe0026daf14c fp: 0xfffffe60bab0bc90
lr: 0xfffffe0024eb6558 fp: 0xfffffe60bab0bd70
lr: 0xfffffe0024eb60e0 fp: 0xfffffe60bab0bdb0
lr: 0xfffffe002480e1fc fp: 0xfffffe60bab0be30
lr: 0xfffffe002480f234 fp: 0xfffffe60bab0bf20
lr: 0xfffffe002477ce78 fp: 0x0000000000000000
Kernel Extensions in backtrace:
com.apple.iokit.IOUSBHostFamily(1.2)[8ACAD8A0-1BA1-3C71-8B2F-850B0B741EE7]@0xfffffe0026d8c220->0xfffffe0026e42703
dependency: com.apple.driver.AppleSMC(3.1.9)[97ECDD11-21A9-3B18-8EF5-F1A228CED252]@0xfffffe0025c40230->0xfffffe0025c6fe33
dependency: com.apple.driver.usb.AppleUSBCommon(1.0)[ADCA3A5F-364E-3C24-9F9C-89C81E8FBA36]@0xfffffe0026052200->0xfffffe00260572a7
dependency: com.apple.driver.AppleUSBHostMergeProperties(1.2)[C3F4720B-B0D9-353D-903D-9CB4F6AAB192]@0xfffffe0026e92940->0xfffffe0026e934df
com.apple.driver.AppleTypeCPhy(1.0)[5CF728DF-CA0E-3EE1-A542-87B44E2955A9]@0xfffffe0025f5eb60->0xfffffe0025f6a6db
dependency: com.apple.driver.AppleARMPlatform(1.0.2)[478C7C28-E159-3083-A01D-1BBB61C10D35]@0xfffffe002513edf0->0xfffffe002518758b
dependency: com.apple.driver.usb.AppleUSBCommon(1.0)[ADCA3A5F-364E-3C24-9F9C-89C81E8FBA36]@0xfffffe0026052200->0xfffffe00260572a7
com.apple.driver.AppleT8103TypeCPhy(1.0)[B3A2DED5-E4D6-34C7-BB2B-79DDF9AF9375]@0xfffffe0025f6ffd0->0xfffffe0025fe4fb7
dependency: com.apple.driver.AppleTypeCPhy(1)[5CF728DF-CA0E-3EE1-A542-87B44E2955A9]@0xfffffe0025f5eb60->0xfffffe0025f6a6db
com.apple.driver.usb.AppleSynopsysUSB40XHCI(1.0)[9A71F376-F811-3A33-8304-B8015F598C89]@0xfffffe0025d304a0->0xfffffe0025d4b24f
dependency: com.apple.driver.AppleARMPlatform(1.0.2)[478C7C28-E159-3083-A01D-1BBB61C10D35]@0xfffffe002513edf0->0xfffffe002518758b
dependency: com.apple.driver.AppleEmbeddedUSBHost(1)[BB469229-CFC6-35F3-B7DB-F32C42DBBD8E]@0xfffffe0025712560->0xfffffe00257157e3
dependency: com.apple.driver.usb.AppleSynopsysUSBXHCI(1)[E161DBBA-64CB-3D55-AFFA-01555097914E]@0xfffffe0025d4b250->0xfffffe0025d6a2e3
dependency: com.apple.driver.usb.AppleUSBCommon(1.0)[ADCA3A5F-364E-3C24-9F9C-89C81E8FBA36]@0xfffffe0026052200->0xfffffe00260572a7
dependency: com.apple.driver.usb.AppleUSBXHCI(1.2)[7B16C9D1-2AA3-361E-8A39-D262AACC6AD9]@0xfffffe0026ee6230->0xfffffe0026f4cecf
dependency: com.apple.iokit.IOAccessoryManager(1.0.0)[4126DA0C-5169-3A09-ACFD-F12BCD08BA9C]@0xfffffe0026555f80->0xfffffe002660080f
dependency: com.apple.iokit.IOThunderboltFamily(9.3.2)[E896F277-30A1-3DDD-8FBE-AE396CD8EEBA]@0xfffffe0026b374c0->0xfffffe0026c52ca7
dependency: com.apple.iokit.IOUSBHostFamily(1.2)[8ACAD8A0-1BA1-3C71-8B2F-850B0B741EE7]@0xfffffe0026d8c220->0xfffffe0026e42703
Ian