Setting up Outlook (the email program that comes with Microsoft Office) is not difficult. But, before you do so, you should make sure you have all your connection information (email username, password, and server) handy because you'll need to provide that information to the program.
MobileMe is now iCloud. You can learn more about it at
here. To register, you'll need a Mac or an iOS device (iPad, iPhone, or iPod).
On a Mac, go to System Preferences > iCloud