Short answer is "yes." The long answer is that I normally just run Onyx under the Automation tab and have every box checked. I've done it that way for years without a problem. I only run Onyx if my Mac starts acting a little goofy. That only happens once every three or four months, so it's not a big deal.
Shop for your Apple, Mac, iPhone and other computer products on Amazon.
We are a participant in the Amazon Services LLC Associates Program, an affiliate program designed to provide a means for us to earn fees by linking to Amazon and affiliated sites.