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Actually, we do know. If SSDs could be made fast, cheap and persistent, someone would build one and sell it as a world-beater. Given no one has done that, it's safe to conclude that persistent memory will always be slower than volatile memory used in RAM. (And the physics supports that, too, as the fast, volatile ram is so ephemeral. Writing a permanent change to a storage device is going to be slower just because of the processes required.)But you don't know if it would be expensive, or super expensive, or super super expensive.
Now, can we rule out some miracle bolt from the blue discovery suddenly changing the entire scenario? No, and you never can do that. But for now the computational physics is getting very close to where quantum mechanics starts to be a really challenging problem and there has not yet been found a way to have fast, cheap, persistent memory. Maybe if we find a room-temperature superconductor then we can all have miracle machines, but until that day...
R&D has to have some basis in reality, unless you are the Government or a University that can throw money at a study of the whichness of what for no real reason. Companies will do R&D in some interesting technologies, but with the goal of improving what they do. Witness IBM's quantum computing project: https://www.research.ibm.com/ibm-q/
If technology improves over the next 50 years as it has in the previous 50, quantum computing will be ubiquitous. Or maybe there will be one massive quantum computer and all of our devices will just use it as the central server for the real work and our local devices (watch, phone, pad, desktop) will just be input-output devices. Who knows?