I played it on my 15" 1st gen MBP (2.0/2GB/256MB vid), though not at native resolution. I think I had it down to 12x7, maybe (was about a year ago)? And yes, quite a few features were turned down. By comparison, playing on an AMD X2 3800+/2GB/7800GT, was significantly better (as you might imagine), though even on that I couldn't run smoothly at 16x10.
Very playable, though, on the Mac, once you lower the settings far enough.
-Chris