Moving the User folder to another hard drive

I have a G% 2.5GHz with two 250GB internal hard drives. On my startup disk I have 4 user accounts in the "Users" folder which are starting to take up rather a lot of disk space. I was wondering if anyone knows of a painless and safe way of moving the default location of the users folder so that it does not have to reside on the startup disk. I read somewhere that it may be possible to do this with NetInfo Manager but when I looked at it it all looked a bit scary and dangerous. Any suggestions would be appreciated.