My wife is up to about 13,000 photos in her iPhoto library and it's really slowing things down. She's using a 2ghz Core Duo iMac with 2 gigs of ram and a 7200rpm 250gb hard drive. There's still a good 70 gigs free left on the hard drive. Any suggestions? She does a lot of shoots and postwork, so she likes to keep everything in one place.