Yes, everything should be there on the discs. In fact, you will be given an option to do either a default install or a custom one. If you choose the latter, you can choose which applications you want. It's more useful if you wish to exclude some things.
Also, once everything is installed, assuming you have a broadband connection, under the Apple in the menu bar, do the Software Update. I found that I actually had to go through it a few times to ensure everything was updated and coordinated. Then you should be fine. Do the update, reboot, and repeat until it comes back clean, saying you're up to date.
Of course, before you do any of this, backup your machine. Once done, verify your backups. If you backup to DVDs, try one or two to see that you've burned things safely to them. Personally, when I switch a hard drive, I make a few sets of backups. I don't like losing data.
To reiterate, replacing the main hard drive on a MacBook is essentially as difficult or easy as replacing one on an IBM ThinkPad. If you can do it on a Windows laptop, you can do it on a MacBook.
Good luck!