Mouse Not Clicking in Panther

I have an odd problem - after starting new program windows the close/minimize/maximize buttons (and in safari the back/forward buttons) are unavailable to me. When i mouse over them they do not change to the x, -, or +. If i move the window then i can click them. My Logitech mouse and Microsoft wireless keyboard are both plugged into the USB ports on my Apple 20" Cinema display.

Hardware

Dual 1GHz POwerPC G4
OS X 10.3.2

originally noticed with my Logitech trackman wheel (corded)
tested with my Microsoft wireless optical mouse same problem.
tested with apple mouse same problem.

Thanks in advance for your help!

I got a similar thing, so i reformatted and it hasn't came back yet