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I am hoping to upgrade the RAM on my 21.5" mid 2010 iMac which is currently running on 4gb's but has a capacity to take up to 16Gb's. I was told that Crucial are the best people to purchase from and have been onto their website to have a look. I can buy either 4 or 8Gb's in packs of 2. My iMac has 4 slots to take the memory and my question is, should I purchase a double pack of 8Gb's which will mean that 2 slots on my iMac will be left empty or do I need to fill all 4 slots using 4Gb memory things/cards? Simply put, will my machines performance/health be affected by leaving 2 slots empty? Any advice greatly welcomed. Thanks