Because Macs sleep and wake up so easily, many Mac users (especially laptop users) tend to never reboot the machine.* Be sure once in a while, perhaps once a week you reboot the machine. That will help free up memory and speed up your machine and help it run cleaner. Especially any time you notice something 'funky' going on or have a program crash - it might be good to reboot, just to have a fresh run at things, as some memory might have gotten tied up in the crash.
Note: one of the stupid ideas Apple had with the introduction of Lion was restarting where you left off - not only will all your apps re-open, but any errors that were present will be as well, so be sure to NOT check the box that says "Reopen windows when logging back in" - that is the worst thing you can do.
A reboot a week is wise. Or at least every other week.
*The other extreme are new Mac users who shut down and reboot every time they leave their computer - which is unnecessary with a Mac! Relax, they are very stable.