The world is your oyster and just depends on your listening needs and budget. If you are after home theater sound or just really like big bottom a sub will add a lot. If you are doing any recording or music production and need really natural sound it is best to avoid a sub. Tell us what you want to listen to, how big of a room do you want to cover, and how much do you want to spend?
I'm running a set of Logitech G51 5.1's right now as a 2.1 setup (well I just setup the center channel today for the heck of it, as I found out the design allows me to sit it on top of a monitor).
These are ballin' speakers! Has a separate control pod, which you can use to adjust each channel volume separately (main/sub/surround/center).
I'm pretty sure they're "gaming" speakers, as they have a sound mode matrix for "game" and "music"
Anyways, they're about $190, and worth every penny.
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