Fast External HD Format Type

I'm going to use a fast 300GB WD VelociRaptor HD in an e-SATA enclosure connected to my MBP via a Merax e-SATA Xpress XpressCard/34 for moving large audio file drum software during live play.

I know FAT32 wont work because of it's 4gig file limitation and stability issues (file corruption). I could use the more modern and stable NTFS but that would require using something like NTFS-3G or Paragon to allow OSX to recognize it but I'm worried about slower performance going that route.

Would using the OSX native HFS+ format give me the performance and large file size usage I need? Thanks

Do you need Windows compatibility with that external disk? If not, HFS+ would be the best option.

Thanks cwa. No this will only be used with OSX.

As cwa107 mentioned, HFS+ is your best bet. If you ever do need to share you data with Windows (or another OS) you can always share the drive via SMB from OSX.

Thanks