2 external hard drives w/ Time Machine

Hello,
Just came out of my 15 year fog and bought a MacBook Pro. Can I use two separate external hard drives (One portable for use on the road and one desktop at home) with Time Machine? Thanks in advance.
~Dave

as in two drives for the time machine backup location itself? It won't be continuous. ie.. it won't have a clue what's been backed up and what hasn't... since it's incremental that would cause headaches.

Why not use one for a bootable back up - SuperDuper or Carbon Copy Cloner and use the other for Time Machine that way u have the best of both, a current back up and historic changes with old copies.