Mac Apps freezing?

it's not really an application in general.. that's freezing.. even though i could give a small list: entourage, dreamweaver, photoshop, flash, firefox.. etc.. not sure what i did.. , but now after having a program run for over like a hour the windows in that app freeze like dreamweaver and i cannot move the internal windows/files that were opened.. its strange.. i had disabled dashboard but put it back thinking that was it.. i have onyx downloaded and did a few things on it.. has anyone had this happen before?