I am using Preview to read papers and take notes.

I wish to highlight parts of the papers also. The problem is that all the journals I use print in a two column format. Is there a way to highlight one column?

Is there another program that you would recommend for reading PDFs. I use the note feature and the highlight feature in Preview. I use Evernote take notes for my research papers as I read over the articles also. I also have MacJournal, but Evernote synchs with my ipod touch. That is handy for meetings.

I am trying to be paperless with this new project so if you have a better idea, please share it.