Safari has been crashing for me every time I open it. It's mostly on sites like YouTube, which leads me to believe that it's a flash problem. When I open the page it just freezes up and the pinwheel just keeps spinning and spinning. I noticed these problems on my MacBook after I upgraded to Snow Leopard, and now they are arising again on my recently purchased Mac Pro (also running SL). I'm running latest version of SL, Safari, and Flash.
I am having the same issue with You Tube on Safari 4.0.3 but in 10.5.8 Leopard on an iMac G5. It's for sure the Flash plug in here as it only happens after a few videos on You Tube that for sure are using Flash.
Interesting enough, on my Intel Mini with 10.6.1 I have not had one crash on the same videos on You Tube.
I have a feeling since Flash is owned by Adobe that they will have to fix the issue with their version of Flash for OSX. Maybe the soon coming 10.6.2 update will have a flash update.