Vice City plays fine on my Core 2 duo old iMac and decent on my Macbook 2007.

I only use a controller for missions where you fly a plane or helicopter. What works great for me is a Logitech I paid $24.99 at Best Buy. Feels and works great,

You have to set up the buttons and controls in GTA VC Setup. Easy to do.

I have won it now 3x on my iMac and Macbook. Great port of the game to OSX!