definitely illustrator. if you want to print from home, i suggest getting an avery template, but if this is a professional business, seek out a print shop :] oh, and if you want the whole card to be .. say.. orange, make sure to have a .25 bleed on it. A standard card is what, like 3.5 x 2? so make sure the doc is 4 x 2.5 with a quarter inch all the way around with crop marks. I don't know if you know a lick of what I just said, but when you take it to a print shop they might be able to assist you! good luck :]